The emergence of antibiotic resistance among food borne pathogens has become a serious problem worldwide. The present study reports antibiotic resistance profile of some food borne bacterial pathogens recovered from retail meat of bovine origin and their relevant resistance genes carried on class I integron in Egypt. Thirty-two Escherichia coli, 15 salmonella and 25 Staphylococcus aureus isolates were assayed for their antimicrobial susceptibilities. Frequent resistances to amoxicillin-clavulanic acid and erythromycin were observed in E. coli and Salmonella species. Moreover, all S. aureus isolates were methicillin-resistant and 52% of the isolates were resistant to each of clindamycin and amoxicillin-clavulanic acid. This is the first report of the comprehensive identification and confirmation of vancomycin resistant S. aureus (VRSA) from meat specimens in Egypt. Interestingly, 31.25, 40 and 48% of E. coli, Salmonella species and S. aureus exhibited features of MDR , respectively. Class 1 integrons were commonly found in 66.67 and 50% of MDR salmonella and E. coli, respectively; while, VRSA isolates were negative. Three different gene cassette arrays encoding resistance to aminoglycoside (aadA2), beta- lactames (blaPSE−1) and trimethoprim and aminoglycosides (dfrA15- aadA1) were characterized among the integrase-positive strains. These findings illustrated the role of retail meat as a potential source for the dissemination of MDR E. coli, salmonella and VRSA in Egypt.