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Class 1 integron and associated gene cassettes mediating multiple-drug resistance in some food borne pathogens
Ammar, A.M1, Attia, A.M2, Abd El-Aziz, N.K3, Abd El Hamid, M.I4, El-Demerdash, A.S5.
The emergence of antibiotic resistance among food borne pathogens has become a serious
problem worldwide. The present study reports antibiotic resistance profile of some food borne
bacterial pathogens recovered from retail meat of bovine origin and their relevant resistance
genes carried on class I integron in Egypt. Thirty-two Escherichia coli, 15 salmonella and 25
Staphylococcus aureus isolates were assayed for their antimicrobial susceptibilities. Frequent
resistances to amoxicillin-clavulanic acid and erythromycin were observed in E. coli and
Salmonella species. Moreover, all S. aureus isolates were methicillin-resistant and 52% of
the isolates were resistant to each of clindamycin and amoxicillin-clavulanic acid. This is the
first report of the comprehensive identification and confirmation of vancomycin resistant S.
aureus (VRSA) from meat specimens in Egypt. Interestingly, 31.25, 40 and 48% of E. coli,
Salmonella species and S. aureus exhibited features of MDR , respectively. Class 1 integrons
were commonly found in 66.67 and 50% of MDR salmonella and E. coli, respectively; while,
VRSA isolates were negative. Three different gene cassette arrays encoding resistance to
aminoglycoside (aadA2), beta- lactames (blaPSE−1) and trimethoprim and aminoglycosides
(dfrA15- aadA1) were characterized among the integrase-positive strains. These findings
illustrated the role of retail meat as a potential source for the dissemination of MDR E. coli,
salmonella and VRSA in Egypt.
Affiliation:
- Zagazig University, Egypt
- Zagazig University, Egypt
- Zagazig University, Egypt
- Zagazig University, Egypt
- Animal Health Research Institute, Egypt
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Indexation |
Indexed by |
MyJurnal (2019) |
H-Index
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0 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus (SCImago Journal Rankings 2016) |
Impact Factor
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- |
Rank |
Q3 (Food Science) |
Additional Information |
0.335 (SJR) |
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