In this study, optimization of Averrhoa bilimbi extraction using Domestic Microwave Maceration Extraction (DMME) was performed using a statistical method called Response Surface Methodology (RSM). RSM could lead to some advantages, such as less number of experiments and cost savings. RSM was used to find condition from each variables (solid to liquid ratio, solvent concentration, and extraction time) that gives optimum response to the yield of phenolic. Yield of phenolic increased in smaller solid to liquid ratio, and gave its best at combination variables of 0% ethanol and 48% ethanol as solvent concentration. Based on the design of experiment, it was known that extraction time variable gave insignificant effect to the yield of phenolic as response. RSM result showed that the optimum DMME extraction condition was found at 1:15 solid-liquid ratio and 34% ethanol as extraction solvent, with 4.2762 mg GAE/g solid as the teoritical yield of phenolic. Validation of RSM model was carried out at the optimal condition and 90 seconds extraction time (the smallest value, to save energy). Yield of phenolic of the model validation was 4.2120 mg GAE/g solid. Error between teoritical yield of phenolic and the validation value was less than 5% (1.5% error value).