The chronic problems of construction include low productivity, low quality, poor co-ordination and high costs. High product cost is also associated with poor quality, inefficiency and high waste generation. Various studies in the construction industry have developed best practices that are not only capable of improving organization’s profit but also assist in producing systematic work processes which encourage the optimal use of resources. A structured questionnaire survey was conducted to provide empirical evidence on levels of significant contribution of waste minimization measures to waste reduction, and levels of practice of same measures using weighted average and coefficient of variation criteria. Purchasing raw materials that are just sufficient, using materials before expiry dates, and using more efficient construction equipment are perceived by construction professionals as three of twenty-six measures which most significantly contribute to waste minimization, and also the three most practiced waste minimization measures in Ghana. Encouraging re-use of waste materials, use of low waste technology and recycling of waste materials on site are, however, considered as the three least significant measures contributing to waste minimization and also least practiced. Among various suggested recommendations, the construction industry is encouraged to sort and re-use waste materials, and adopt environmentally friendly and low waste technologies on site. This paper presents measures which significantly contribute to materials waste minimization on construction sites in Ghana.