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Comparison of Morphine with Fentanyl Added to Intrathecal 0.5% Hyperbaric Bupivacaine for Analgesia After Caesarean Section
Siti Salmah, G1, Choy, Y.C2.
This was a prospective randomised, controlled, single-blind study done to determine the effect of intrathecal morphine 0.1 mg as compared with intrathecal fentanyl 25 µg in terms of analgesia and duration for postoperative pain relief after Caesarean section. Sixty ASA I or II parturients were randomised into two groups. Group 1 (n=33) received 1.8ml of 0.5% hyperbaric bupivacaine combined with 0.1mg morphine while Group 2 (n=27) received 1.8ml of 0.5% hyperbaric bupivacaine combined with 25µg fentanyl for spinal anaesthesia. Postoperatively, all patients were provided with patient controlled analgesia (PCA) morphine. Pain was assessed using visual analogue score (VAS) at 6, 12, 18 and 24 hours. Time to first demand of PCA morphine, cumulative PCA morphine requirement and opioid side effects were documented. The VAS for pain and the cumulative PCA morphine requirement were both significantly lower in Group 1 (p<0.05) during the 24 hours study period. The time to first demand was also significantly longer in Group 1 (p<0.05). Overall, there were no significant difference between the two groups in side effects, except for a high incidence of nausea and vomiting requiring treatment in Group B in the first six hours. In conclusion the addition of 0.1mg morphine for spinal anaesthesia provided superior and longer postoperative analgesia after Caesarean section.
Affiliation:
- Universiti Kebangsaan Malaysia, Malaysia
- Universiti Kebangsaan Malaysia, Malaysia
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Indexation |
Indexed by |
MyJurnal (2019) |
H-Index
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0 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus (SCImago Journal Rankings 2016) |
Impact Factor
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- |
Rank |
Q3 (Medicine (miscellaneous)) |
Additional Information |
0.248 (SJR) |
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