Melastoma malabathricum L. is widely used in Malay traditional practices utilizing each and every part of this plant (Burkill, 1966). It is scientifically proven that this plant has several properties including antibacterial (Zulaikah et al., 2008), antiviral (Lohezic-Le Devehat et al., 2002) antioxidant (Susanti et al., 2007) and anti inflammatory (Mazura et al., 2007) activities. Despite the successes in the treatment of some virus diseases during the past three decades, the search for new antiviral drugs remains an area of active investigation. Effective treatment is not available for many viral infections. Moreover, the selection of resistant and cross-resistant mutants caused partially by the narrow spectrum of the mechanism of activity, as well as potential toxic side-effects demand the discovery of new drugs.