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Antioxidant and anti-inflammatory activity of aqueous fraction from Albizia lebbeck leaves
Praengam, K1, Muangnoi, C2, Charoenkiatkul, S3, Thiyajai, P4, Tuntipopipat, S5.
The present study used in vitro digestion coupled with Caco-2 cells to assess antioxidant and
anti-inflammatory activities of an aqueous fraction from Albizia lebbeck (A. lebbeck) young
leaves collected from 3 provinces of Thailand i.e.; Suphanburi (SP), Nakhonratchasima
(NA) and Kanchanaburi (KA). A. lebbeck young leaves from SP had the highest content of
flavonoids while those from KA possess the highest of carotenoids. The aqueous fraction of A.
lebbeck young leaves from SP had the highest antioxidant capacity. Pre-treatment of Caco-2
cells monolayer with the aqueous fraction of A. lebbeck young leaves from SP significantly
restored intracellular glutathione content and glutathione peroxidase activity induced by
H2O2+IL-1β. Pre-incubation of Caco-2 cells monolayer with the aqueous fraction of A. lebbeck
young leaves from 3 provinces significantly decreased secretion of IL-8 and MCP-1. Similar
to the antioxidant capacity, the aqueous fraction of A. lebbeck young leaves from SP had the
highest anti-inflammatory capacity. Pre-treatment of Caco-2 cells monolayer with the aqueous
fraction of A. lebbeck young leaves from 3 provinces significantly decreased TNF-α and IL-6
production and COX-2 protein expression but there was no statistically difference noted in
suppressive effect among samples from 3 provinces. The present data indicated that digested
active compounds in A. lebbeck young leaves retained their antioxidant and anti-inflammatory
capacity and enhanced cytoprotective effects by reducing potential damage caused by oxidative
stress and inflammatory insult.
Affiliation:
- Mahidol University, Thailand
- Mahidol University, Thailand
- Mahidol University, Thailand
- Mahidol University, Thailand
- Mahidol University, Thailand
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Indexation |
Indexed by |
MyJurnal (2018) |
H-Index
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8 |
Immediacy Index
|
0.000 |
Rank |
28/30,Q4(Sciences ) 28/30,Q4(Sciences ) 14/17,Q4(Medical & Health Sciences )
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Indexed by |
Scopus (SCImago Journal Rankings 2016) |
Impact Factor
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- |
Rank |
Q3 (Food Science) |
Additional Information |
0.335 (SJR) |
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